Cancer Prevention and Research Institute of Texas awards $49M in grants for cancer research

Austin-based Cancer Prevention and Research Institute of Texas issued $49 million in grants toward cancer research and technology development. Here is a list of the organizations receiving the money:

  • The University of Texas at Arlington received $250,000 for ultrasensitive nanosensor-based detection of tumor immunogenic peptides to enable personalized cancer immunotherapy.
  • The University of Texas at Austin received three grants:
    • $249,999 for research into novel covalent drugs for BCL6
    • $3,995,180 for research into advanced protein therapeutics core
    • $249,932 for novel modulators of genomic instability in human cells
  • Dallas-based University of Texas Southwestern Medical Center received four grants:
    • $3 million to establish the Accelerating Clinical Oncology Research Network-Texas to enhance clinical trial access in North and Central Texas  
    • $4 million to establish new Cryo-EM core services to drive cancer research and drug discovery at UT Southwestern Medical Center
    • $250,000 to develop a novel optogenetic recombinase system to study and target metastatic cancer
    • $237,501 to research the impact of immunity on pre-malignant somatic mosaicism and cancer prevention
  • Dallas-based Texas A&M University System Health Science Center received $237,500 for a glia-to-neuron conversion for treating oral cancer pain.
  • Dallas-based ImmuneSensor Therapeutics received $16,154,562 for a phase 2 clinical trial to evaluate the safety and efficacy of IMSA101 in combination with radiotherapy and checkpoint inhibitors in solid tumor malignancies.
  • The University of Texas Medical Branch at Galveston received $1,494,784 for hyperspectral, quantitative intraoperative fluorescence image-guided brain surgery.
  • Houston-based University of Texas MD Anderson Cancer Center received five grants:
    • $1.5 million for CPRIT Early Clinical Investigator Award to Christopher Alvarez-Breckenridge, MD, PhD
    • $249,976 for reversing aging-associated resistance to cancer immunotherapy  
    • $249,999 for fasting-induced microbiome changes and radioprotection
    • $250,000 for restoration of phagocytosis function of glioma-associated microglia/macrophage by activating QKI-PPARb-RXRa
    • $250,000 for identification of enhancers of T-cell anti-tumor activity in PDAC using CRISPR activation screening
  • Houston-based Methodist Hospital Research Institute received two grants:
    • $250,000 for targeting NHE6 to improve clinical efficacy of daratumumab in myeloma    
    • $250,000 for targeting nitric oxide synthase pathway to remodel obesity-induced tumor inflammation in patients with TNBC
  • Houston-based Baylor College of Medicine received two grants:
    • $3,999,996 for Patient-Derived Xenograft and Advanced In vivo Models Core Facility of Texas
    • $250,000 for targeting tumors and the tumor microenvironment with banana lectin-expressing T-cells
  • Lubbock-based Texas Tech University received $249,999 for in vivo Akt analysis via chemical genetics and nanoparticle-mediated probe delivery.
  • Lubbock-based Texas Tech University Health Sciences Center received $3,369,480 for West Texas Pharmacology Core.
  • The University of Texas Health Science Center at San Antonio received two grants:
    • $3,935,480 for Texas Pediatric Cancer Testing Core
    • $3,998,688 for an unstated purpose

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