Researchers studied breast tumor and non-tumor samples from 144 patients, utilizing single-cell mass cytometry to quantify the 70 proteins in each of 26 million individual cells before turning to machine learning processes to seek out patterns and relationships in that data. With those models, the scientists were able to create a “detailed atlas” of breast cancer ecosystems.
This analysis and resulting atlas prove that each breast cancer tumor carries a unique cellular composition, highlighting the need for individualized, precision treatments. The research also provides insight into those potential treatments: The discovery of certain immune cell types in one group of the studied tumors, for example, suggests that immunotherapy could be an effective treatment for some breast cancer patients.
The study’s authors wrote in a blog post that they plan to initiate subsequent studies into the proposed immunotherapy treatments, with the hope of achieving results that could eventually lead to clinical trials.
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