Does pre, intraoperative antibiotic use increase risk of postoperative drug resistance?

Taking antibiotics before or during elective surgical procedures does not increase risk of postoperative antibiotic resistant infections, according to a study published in the Journal of the American College of Surgeons.

Researchers conducted a retrospective cohort study. They examined 689 adults who underwent elective surgical procedures and developed infections within 30 days, post-operation. They defined postoperative antibiotic resistant infections as positive culture results from any site within one month, showing intermediate or nonsusceptibility across one or more antibiotic classes.

Among the 689 adults studied, 338 had postoperative antibiotic resistant infections. Taking antibiotics anytime from one hour before first incision until the end of the operation was not associated with postoperative antibiotic resistant infections, however.

Having previous antibiotic resistant infections was linked to a risk for developing postoperative antibiotic resistant infections, the study shows.

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