Four details:
- Lenzilumab seeks to neutralize GM-CSF, a cytokine linked to hospitalization and death in COVID-19 patients.
- The announcement is based on data from a 520-participant phase 3 clinical trial. Patients in both the lenzilumab and placebo groups were given other treatments, such as steroids and remadesivir.
- The Kaplan-Meier estimate for invasive mechanical ventilation and/or death was 15.6 percent for the lenzilumab group, compared to 22.1 percent for the placebo group.
- Humanigen said it has met its primary endpoint for the drug and plans to use the data to apply for FDA emergency use authorization.
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