The writers reported the increased sensitivity to pain following morphine is due to the activation of an immune system receptor, TLR4, designed to detect harmful bacteria.
The study also found when morphine is metabolized in a patient’s body, one metabolite, M6G, can enter the nervous system and relieve pain, but another metabolite, M3G, has no pain-relieving role.
One of the findings was if morphine could be administered along with a molecule to inhibit TLR4, then the unwanted pain could be reduced.
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