With cancer care growing beyond hospital walls and more cancer patients surviving than ever before, health systems in the U.S. are doubling down on their oncology infrastructure commitments.
“Cancer care can no longer be designed around treatment alone. We must intentionally redesign oncology as a continuum of care, where survivorship is not an afterthought but a core clinical strategy,” Robert Stone, CEO at Duarte, Calif.-based City of Hope, told Becker’s.
As breakthroughs in precision diagnostics and cellular therapies accelerate at a rapid pace, leaders are tasked with balancing lifesaving but expensive cancer care investments with other system priorities.
“Hospital and health system leaders often underestimate the complexity of patient selection, treatment timing and site-of-care decisions,” Armin Ghobadi, MD, bone marrow transplant specialist and medical oncologist at St. Louis-based Siteman Cancer Center, told Becker’s. “Ultimately, successful immunotherapy programs depend on tight alignment between clinical expertise, operational authority and sustainable financial models — recognizing immunotherapy as an enduring service line rather than a one-time therapeutic event.”
Here is how 16 health systems plan to spend more than $4 billion in cancer care service expansions to expand capacity, decentralize access and sustain the next generation of oncology care:
Editor’s note: This list is not exhaustive. Read about $2 billion in previously reported cancer infrastructure investments here.
- Livonia, Mich.-based Trinity Health will invest $22.7 million in renovations at the Trinity Health Grand Rapids (Mich.) Richard J. Lacks Sr. Cancer Center. The cancer center will remain open during construction, which is expected to be completed in fall 2028.
- Evansville, Ind.-based Deaconess Health System will build a new cancer center. Expected to open in 2028, the Cinelli Cancer Center will cost more than $150 million. The health system has raised $35 million for the project to date.
- Rochester (N.Y.) Regional Health broke ground on an $8.9 million oncology expansion and a $12 million outpatient imaging center at its Unity campus.
The Lipson Cancer Institute project will double infusion capacity from 10 to 20 bays and add a dedicated oncology pharmacy. The new outpatient imaging center, scheduled to open in late 2026, will offer MRI, CT, DEXA, X-ray, mammography and ultrasound services. - Coral Gables, Fla.-based Baptist Health South Florida received $2 million in support of the Al and Jane Nahmad Women’s Cancer Center at Baptist Health Miami Cancer Institute, part of Baptist Health Cancer Care.
Expected to open in 2027, the Nahmad Women’s Cancer Center will serve patients with breast, gynecologic and skin cancers in one freestanding facility. - Gastonia, N.C.-based CaroMont Health will invest $200 million to expand oncology services through three projects: a new hematology and oncology physician office in Belmont, N.C., a new cancer center in Gastonia and a new radiation therapy center in Belmont.
“We are not simply expanding our footprint, we are building an integrated oncology network designed around the way patients and families actually experience care,” President and CEO Chris Peek said in an April 16 health system news release. “When care is connected, outcomes are better, the experience is better and the burden on families is lighter.”
- Northern Arizona Healthcare began construction on a $39.5 million cancer center at its Cottonwood, Ariz.-based Verde Valley Medical Center campus. The cancer center is expected to open September 2027.
Northern Arizona Healthcare is a nonprofit health system with medical campuses in Cottonwood and Flagstaff, serving more than 750,000 residents, including tribal communities. - Morgantown, W.Va.-based WVU Medicine broke ground on a $122 million cancer care facility in Wheeling, W.Va.
The WVU Cancer Institute St. Joseph Regional Cancer Complex is being constructed on the site of the former Ohio Valley Medical Center and is expected to open in fall 2028. - Columbus-based OhioHealth began construction on a $226 million outpatient cancer center at its administrative campus, with completion expected in late 2028.
The health system is partnering with Columbus Oncology & Hematology on the center, expanding an existing relationship that includes cancer centers in Dublin and Westerville, Ohio. As part of the project, Columbus Oncology & Hematology will relocate its Jasonway Avenue practice to the new site. - Tampa (Fla.) General Hospital received $10 million to establish the Ian and Jean MacKechnie Immunotherapy Lab within the Tampa General Hospital Cancer Institute. The lab will be housed in the USF Health building in downtown Tampa and operate in partnership with the University of South Florida.
- NYC Health + Hospitals/South Brooklyn Health invested $2 million to renovate its oncology and infusion center, expanding the center’s capacity from five to 13 exam rooms and from seven to 11 infusion bays.
- Naples (Fla.) Comprehensive Health received $10 million to fund women’s cancer care services across multiple NCH facilities, including an outpatient infusion center and the women’s oncology surgical wing at NCH North Hospital.
- Sioux Falls, S.D.-based Avera Health received more than $10 million in federal funding to improve rural cancer care services. The system will use the funds to purchase a fixed PET/CT scanner for the Avera Cancer Institute in Yankton, S.D., and replace linear accelerators in three regional hubs.
- Portland-based Oregon Health & Science University will open a $650 million cancer center in April. The Vista Pavilion will house 128 inpatient beds dedicated to treating cancer through the OHSU Knight Cancer Institute.
In August, the Knight Cancer Institute at Oregon Health & Science University received a $2 billion gift from Phil and Penny Knight to establish a new cancer care delivery model. - The Medical University of South Carolina board of trustees advanced plans for a $1.1 billion cancer hospital in Charleston aimed at centralizing inpatient and outpatient oncology services.
MUSC said the estimated cost of the new cancer hospital is $1.115 billion, including approximately $885 million for construction and $230 million for equipment and furnishings. - In April, Bend, Ore.-based St. Charles Health System will open a cancer center in Redmond, Ore., that can serve up to 300 patients per day.
The facility will be nine times larger than the system’s current cancer care facilities in Redmond and cost $65 million to build. - Boston-based Massachusetts General Hospital — part of Somerville, Mass.-based Mass General Brigham — received $35 million from Irving Oil to fund two cancer-focused facilities within the Phillip and Susan Ragon Building, currently under construction.
The funds will establish the Irving Oil Limited Center for Urgent Cancer Care in Honor of Arthur L. Irving and the Irving Oil Limited Healing Garden in Honor of Arthur L. Irving.
The urgent care will be housed in the Ragon Building’s Herb Chambers Tower, which is expected to open in 2027. The healing garden will be located in the Ragon Building’s New Balance Foundation Tower, expected to open in 2030. - Boston-based Dana-Farber Cancer Institute received the largest single gift in the institute’s history from the Josh and Anita Bekenstein and the Jonathan and Jeannie Lavine families. The gift will support the cancer institute’s future inpatient hospital, which will be named in honor of the families.
Construction on the new hospital is expected to begin in mid-2026. The $1.68 billion, 300-bed cancer hospital will be owned and operated by Dana-Farber, and supported by a clinical collaboration among Dana-Farber, Boston-based Beth Israel Deaconess Medical Center and Harvard Medical Faculty Physicians. - Kansas City-based University of Kansas received $36 million in federal funding to support research facilities within the University of Kansas Cancer Center, currently under construction. The university began construction of the cancer center in May after receiving a $100 million gift from the Sunderland Foundation.
- Wenatchee, Wash.-based Confluence Health will open a nearly $60 million cancer center at its Central Campus in 2028. The new facility will increase exam rooms by 38%, medical infusion chairs by 76% and double radiation capacity with the addition of a second linear accelerator vault.
- Hartford HealthCare’s St. Vincent’s Medical Center in Bridgeport, Conn., will leverage a $15 million gift — one of the largest in Hartford HealthCare’s history — from the estate of Neil Mellen to expand and modernize its inpatient oncology unit.
The donation will support upgrades at the Hartford HealthCare Cancer Institute at St. Vincent’s, a care partner of Memorial Sloan Kettering Cancer Center. Planned improvements include advanced treatment spaces, patient comfort enhancements and new clinical technology. - Los Angeles-based Cedars-Sinai will establish the Cedars-Sinai Cayton BRCA Center after receiving a $30 million gift from the Cayton Goldrich Family Foundation.
The new center will focus on research, diagnosis and treatment of cancers linked to mutations in the BRCA1 and BRCA2 genes, as well as offer genetic testing, specialized screenings, risk-reducing procedures and reproductive medicine services. - Smilow Cancer Hospital at Greenwich in Connecticut will use funding from a $25 million gift to renovate and expand the cancer care facilities within the hospital’s Olive and Thomas J. Watson Pavilion, and the Sherman and Gloria H. Cohen Pavilion.
- Worcester, Mass.-based UMass Memorial Health received approval from state regulators to build a $54 million cancer care facility that will offer proton therapy. Officials with UMass Memorial Health said they anticipate patients to begin receiving treatment at the facility in February 2028.
- Washington, D.C.-based Johns Hopkins Kimmel Cancer Center at Sibley Memorial Hospital will establish a Pediatric Radiation Oncology Research Center through $40 million in philanthropic funding. The center will operate out of Johns Hopkins’ existing proton therapy center at Sibley Memorial Hospital.
The new center will collaborate with institutions including Boston-based Mass General Brigham for Children, Baltimore-based Kennedy Krieger Institute, Children’s Hospital of Philadelphia and Washington, D.C.-based Children’s National Hospital. - Philadelphia-based Penn Medicine and Penn Medicine Princeton (N.J.) Health broke ground on a $401 million cancer center in October.
The Penn Medicine Princeton Cancer Center is expected to open in May 2028 and will house more than 40 exam rooms, 30 infusion chairs, two linear accelerators for radiation therapy and a breast imaging center. - Allentown, Pa.-based Lehigh Valley Health Network, part of Philadelphia-Jefferson Health, opened the Peter and Odete Kelly Center for Personalized Cancer Immunotherapy at the Lehigh Valley Hospital-Cedar Crest, also in Allentown.
The center was established through a $12 million gift from Peter and Odete Kelly. - New Hyde Park, N.Y.-based Northwell Health opened a $14 million outpatient facility dedicated to breast and gynecologic cancers.
The center houses 26 exam rooms, 10 consultation rooms, two procedure rooms and an on-site laboratory. Support services such as infusion therapy, radiation medicine, plastic surgery, genetic counseling, genomic testing, imaging and access to clinical trials are located in the same building. - Sacramento, Calif.-based Sutter Health will build the Jean and E. Floyd Kvamme Advanced Cancer Center after receiving a $30 million gift. Expected to open in 2030, is part of a larger $50 million effort to “revolutionize cancer care and research” for Sutter Health’s community.
Sutter Health also began construction on the Advanced Cancer Center and Care Complex in Modesto, Calif. Estimated to cost $380 million and open in 2029, the center will offer clinic visits, screening, infusion and radiation therapy, imaging, lab and pharmacy services, as well as an ambulatory surgery center and expanded patient access to clinical trials. - The University of Chicago Medicine is expected to open an $815 million cancer center and research pavilion in 2027, the first facility of its kind in Chicago.
Editor’s note: This article was updated May 11, 2026 at 9:05 am CT.
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