Rochester, Minn.-based Mayo Clinic’s board of trustees elected Matthew Callstrom, MD, PhD, medical director for Mayo Clinic Strategy and the system’s AI program, as its next president and CEO.
Dr. Callstrom will succeed Gianrico Farrugia, MD, who will remain president and CEO through Dec. 31 and work with Dr. Callstrom on the transition. Dr. Farrugia, who has led the system since January 2019, announced in May that he would step down at the end of 2026.
“Dr. Farrugia has led Mayo Clinic through a period of extraordinary transformation and progress while remaining steadfastly focused on our primary value: the needs of the patient come first,” said Richard Davis, chair of the Mayo Clinic board of trustees, in a news release. “His leadership has strengthened Mayo Clinic and created tremendous momentum for the future. The board is deeply grateful for Dr. Farrugia’s continued service and contributions, including significant investments in Mayo Clinic’s people, physical and digital infrastructure, education, research, AI and new care models, which leave Mayo Clinic so well positioned for its next chapter.”
Under Dr. Farrugia, Mayo Clinic launched its “Bold. Forward.” strategy and built Mayo Clinic Platform, its AI-enabled care transformation platform. Dr. Callstrom will inherit a system that posted an 8.6% operating margin on $501 million in operating income in the second quarter of 2026. His election puts the physician who led Mayo’s AI integration work in charge of scaling it.
Dr. Callstrom joined Mayo Clinic in 2002 and sits on its board of governors and board of trustees. He previously served as interim chief strategy officer and chair of the department of radiology at Mayo Clinic in Rochester.
A body interventional radiologist, Dr. Callstrom specializes in image-guided cancer treatment. His work has produced more than 200 publications and patents, and he previously served as president of the Society of Interventional Oncology.
“Dr. Callstrom combines a deep understanding of Mayo Clinic with the ability to see what is coming next and bring people together to turn possibility into meaningful change for patients,” Mr. Davis said. “He understands Mayo Clinic as a physician caring for patients, a scientist translating discovery into clinical care and a leader shaping our strategy for the future. That combination is invaluable as Mayo Clinic continues to advance its mission and transform healthcare.”
Dr. Callstrom brings nearly 25 years of leadership across patient care, research, strategy and innovation to his new role.
“I am deeply honored to have the opportunity to lead Mayo Clinic in this moment, serving alongside colleagues whose expertise, curiosity and commitment to our patients inspire me every day,” he said. “Mayo Clinic has always been at its best when we bring the full power of our clinical expertise, science and innovation to the needs of the patient. Now, we have an opportunity to build on that foundation – accelerating the translation of discovery and emerging technologies into better care and extending Mayo Clinic’s impact to more patients, wherever they are.”
