For the study, researchers assessed Tideglusib’s ability to prompt stem cell activation in the damaged teeth of mice. They inserted biodegradable collagen sponges, soaked in Tideglusib, into the mice’s cavities and sealed them for several weeks.
Researchers discovered the drug successfully activated stem cells inside the mice teeth, causing damaged areas to regenerate the hard dentin material that makes up the majority of a tooth, according to the report.
“The simplicity of our approach makes it ideal as a clinical dental product for the natural treatment of large cavities, by providing both pulp protection and restoring dentin,” said lead author Paul Sharpe, PhD, professor and researcher at King’s College London, according to Science Alert. “In addition, using a drug that has already been tested in clinical trials for Alzheimer’s disease provides a real opportunity to get this dental treatment quickly into clinics.”
Researchers plan to next study the process in rats, before potentially moving to clinical trials.
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