The publication identified a “growing body of evidence” that suggests sometimes immune systems do not respond appropriately to flu shots and fail to make antibodies against designated strains. The reason for this is “imprinting.”
Imprinting, or “original antigenic sin,” is the phenomenon that human immune systems will always be best equipped to defend against the first flu virus they were exposed to. For example, someone whose first influenza A infection was caused by an H3N2 virus will demonstrate a better immune response to this component of a flu vaccine than an H1N1 component, according to STAT.
“We’ve all been trained on different influenza viruses,” Scott Hensley, PhD, an associate professor of microbiology and vaccine researcher at Philadelphia-based University of Pennsylvania, told STAT. “If you vaccinate 100 people, guess what? They’re all going to respond differently. We think a large part of that is that we all have a different immunological imprint.”
More articles on clinical leadership and infection control:
Antimicrobial lock solutions cost-effective for CLABSI prevention
Physician viewpoint: Why providers need to stop unneeded MRIs, CT scans
AORN: 3 ways to cultivate nurse resiliency
At the Becker's 11th Annual IT + Revenue Cycle Conference: The Future of AI & Digital Health, taking place September 14–17 in Chicago, healthcare executives and digital leaders from across the country will come together to explore how AI, interoperability, cybersecurity, and revenue cycle innovation are transforming care delivery, strengthening financial performance, and driving the next era of digital health. Apply for complimentary registration now.
