A. baumannii, P. aeruginosa cause 80% of CR infections in the US

The majority of carbapenem-resistant gram-negative infections in the U.S. are caused by Acinetobacter baumannii and Pseudomonas aeruginosa bacteria, according to a study published in Open Forum Infectious Diseases.

Researchers used the Premier Healthcare Database to identify hospitalized patients with infections due to four CR gram-negative bacteria species:

●    Acinetobacter baumannii
●    Pseudomonas aeruginosa
●    Klebsiella pneumoniae
●    Escherichia coli

From 2009 to 2013, 4.5 percent (13,262) of 292,742 infections due to the aforementioned gram-negative pathogens were carbapenem-resistant.

Of these CR infections, 82.3 percent were caused by A. baumannii (22 percent) or P. aeruginosa (60.3 percent). K. pneumoniae or E. coli caused 17.7 percent.

The crude all cause in-hospital mortality was greater for most of the CR cohorts compared with the carbapenem-susceptible cohort, especially for A. baumannii infection in blood.

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