USP’s list of vulnerable medications: What to know

The U.S. Pharmacopeia has published its 2024-2025 Vulnerable Medicines List, identifying 100 drugs at risk of supply disruptions in the U.S. 

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The list includes 49 medications for chronic conditions and 51 for acute care, with an aim of informing efforts to improve supply chain reliability, according to a March 4 news release from the nonprofit organization. 

The analysis, based on data from sources including the USP Medicine Supply Map, found that 71% of the drugs identified as the most vulnerable are injectables, including sodium chloride injection, dextrose injection, heparin sodium injection, propofol and lidocaine hydrochloride injection. 

The report also highlights that while 61% of the medicines listed were not in shortage as of January 2025, they remain at high risk of shortage. 

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