Lung cancer drug candidate fails to meet primary endpoint in phase 3

In a phase 3 trial, an investigational cancer drug from AstraZeneca and Daiichi Sankyo did not improve overall survival rates, and some patients died during the study, the organizations said July 3. 

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The drug candidate is datopotamab deruxtecan, an experimental therapy for locally advanced or metastatic non-small cell lung cancer in patients who have been treated with another chemotherapy — such as docetaxel, the standard treatment that is in short supply. 

In a news release, AstraZeneca said the study will “continue as planned to assess overall survival with greater maturity.” No new safety concerns were noted in the phase 3 trial, and “some Grade 5 events [deaths] were observed.”

The candidate met its endpoint of progression-free survival.

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