For-profit health systems continued to reshape their portfolios in 2025, using acquisitions and divestitures to sharpen strategic focus, exit non-core markets and expand regional footprints.
This year, several notable transactions have closed — or are in progress — including deals that mark multimillion-dollar regional expansions and complete market exits.
Here are 15 for-profit hospital transactions that have been announced or completed in 2025:
Community Health Systems (Franklin, Tenn.)
1-3. CHS signed a letter of intent in July to sell Commonwealth Health, a three-hospital system in Scranton, Pa., to nonprofit organization Tenor Health Foundation. Commonwealth Health’s hospitals include Regional Hospital of Scranton, Moses Taylor Hospital in Scranton and Wilkes-Barre General Hospital. The deal would see CHS exit Pennsylvania.
4. CHS on April 1 sold Lake Norman Regional Medical Center in Mooresville, N.C., to Durham, N.C.-based Duke University Health System for $284 million. The 123-bed hospital was renamed Duke Health Lake Norman Hospital.
5-6. CHS sold ShorePoint Health-Port Charlotte (Fla.) and certain assets of ShorePoint Health-Punta Gorda (Fla.) to Altamonte Springs, Fla.-based AdventHealth for $260 million, effective March 1.
7. CHS sold Merit Health Biloxi (Miss.), a 153-bed hospital, to Gulfport, Miss.-based Memorial Health System, effective Jan. 31. With the acquisition of Merit Health Biloxi, Memoria Health grew to a three-hospital system.
8. CHS signed a definitive agreement to sell its 80% ownership interest in two joint ventures — which own and operate Tennova Healthcare-Clarksville (Tenn.) — to Vanderbilt University Medical Center. The $600 million deal, announced Oct. 30, includes the 270-bed hospital in Clarksville and ancillary businesses.
HCA Healthcare (Nashville, Tenn.)
9. HCA sold Regional Medical Center, a 252-bed facility in San Jose, Calif., to the County of Santa Clara for $175 million, effective April 1. The hospital is now part of San Jose-based Santa Clara Valley Healthcare, which operates the county’s public health system.
10. Nashville, Tenn.-based HCA Healthcare acquired Catholic Medical Center, a 330-bed regional health system in Manchester, N.H., effective Feb. 1. HCA also operates three other hospitals in New Hampshire: Parkland Medical Center in Derry, Portsmouth Regional Hospital and Frisbie Memorial Hospital in Rochester.
11. HCA acquired Lehigh Regional Medical Center in Lehigh Acres, Fla., from Ontario, Calif.-based Prime Healthcare in February. The 53-bed hospital has been renamed HCA Florida Lehigh Hospital and is part of HCA’s west Florida division.
12. Terre Haute-based Union Hospital and HCA’s Terre Haute Regional Hospital merged Dec. 13 after the Indiana Department of Health issued a certificate of public advantage for the transaction.
Prospect Medical Holdings (Los Angeles)
13. Farmington, Conn.-based UConn Health received state approval to acquire Prospect Medical’s Waterbury Hospital in mid-November after submitting a $13 million bid to take it over. UConn Health plans to invest around $250 million over the next five years into the hospital.
Summa Health (Akron, Ohio)
14-15. Summa Health, a two-hospital system, finalized a deal with General Catalyst’s Health Assurance Transformation Company. The $485 million transaction, completed Oct. 1, transitions Summa into a for-profit health system backed by a “significant investment” from HATCo, a subsidiary of the venture capital firm General Catalyst.
