Which disinfectants work best against C. diff?

Researchers in the Netherlands compared the effectiveness of four different products on killing distinctive Clostridium difficile PCR ribotypes and recently published their results in the journal Antimicrobial Resistance & Infection Control.

According to the study, a dilution of hypochlorite is typically used to disinfect areas contaminated with C. diff, but "hypochlorite has to be used in excessive concentrations to be effective, thereby increasing its toxic and corrosive properties." So they searched for alternative agents to get rid of C. diff.

Three of the four compounds tested came in wipe and spray form, while the last compound came only in spray form.

The four compounds were:

  • Glucoprotamin
  • Hydrogen peroxide
  • Ethanal, propane, amino propyl glycine
  • Didecyldimonium chloride, benzalkonium chloride, polyaminopropyl, biguanide, dimenthicone (spray only)

Researchers found wipes performed better than sprays with the same active ingredients, and wipes with hydrogen peroxide "showed the highest bactericidal activity," the study concluded.

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