Researchers performed a meta-analysis of 14 observational reports published from January 2000 to March 2014. Those studies involved 9,715 critically ill patients and vitamin D concentrations.
The results show that vitamin D deficiency, defined as concentrations below nmol/L, is associated with higher rates of infection, sepsis, 30-day mortality and in-hospital morality in adult critically ill patients around the globe.
“This information may help to design placebo-controlled randomized clinical trials on vitamin D supplementation in preventing severe infections and death in the ICU,” the researchers concluded.
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