For their study, researchers assessed 187,912 hospitalized patients and 208,468 controls. The highest rate of medication discontinuation occurred in the antiplatelet or anticoagulant agent group. In this group, there were 552 patients (22.8 percent) with an ICU admission who discontinued these medications after hospital discharge, compared to 11.8 percent of patients in the control group at 90 days.
The authors also found that there was an increased risk of medication discontinuation in patients with an ICU admission compared with nonhospitalized patients. One-year follow-up of patients who discontinued medications showed an elevated risk for the secondary composite outcome of death, emergency department visit or emergent hospitalization in the statins group and in the antiplatelet/anticoagulant agents group.
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