EV-D68 has caused serious respiratory infections in children in the United States and elsewhere and may even be associated with polio-like symptoms like muscle weakness and paralysis.
Using a technique called X-ray crystallography to study the structure of the original strain of EV-D68, researchers discovered a molecule called a “pocket factor” located within the virus’ protective shell. The pocket factor squeezes out of its shell when the virus binds to a human cell and causes the destabilization of the virus particle and the replication of its genetic material.
The researchers discovered that when an anti-viral compound called pleconaril also binds to the pocket, the infection is inhibited, according to the report.
Pleconaril is not currently active against tested strains of EV-D68, but it is active against the original isolate which means small changes in the structure of pleconaril can lead to anti-EV-D68 inhibitors against a broader spectrum of isolates.
More articles on infections:
Flu now widespread in 43 states; 6 new deaths reported
Top 10 infection control stories, Dec. 29-Jan. 2
Possible measles exposure at CVS in Pennsylvania
