While studying the effects of NSAIDs on E. coli, researchers observed the drugs prevented activation of genes for DNA replication and repair in the bacteria, destroying the organisms in a completely different way than conventional antibiotics, according to a Forbes report on the study.
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The NSAIDs studied were bromofenac, carprofen and vedaprofen, which are often used in veterinary medicine.
While more research remains, the effect NSAIDs have on bacterial replication may be used as a starting point for creating new, more effective classes of antibiotics in the fight against MDR organisms, according to one of the study’s authors quoted in Forbes.
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