NAP1 Strain of C. diff Linked to Highest Mortality

The fluoroquinolone-resistant North American pulsed-field gel electrophoresis type 1 strain of Clostridium difficile was found to be linked to greater odds of adverse events, according to a study in Clinical Infectious Diseases.

Researchers analyzed more than 2,000 C. diff infections to identify the link between certain strains and certain adverse events.

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Of all C. diff cases, 17.7 percent resulted in severe disease, 4.9 percent resulted in a severe outcome and 2.7 percent resulted in 14-day mortality.

Researchers found the NAP1 strain to be the most common, accounting for 28.4 percent of all infections, followed by NAP4 (10.2 percent) and NAP11 (9.1 percent).

Additionally, the NAP1 strain was the strain most likely to cause severe disease, severe outcome and 14-day mortality.

Researchers suggest strategies to reduce NAP1 infection, including antimicrobial stewardship programs and reduced fluoroquinolone use, may help reduce mortality rates.

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