Researchers analyzed adult hospitalization and pharmacy data from the Truven Health MarketScan Hospital Drug Database, 2006-2010. They identified a cohort of hospitalized patients and determined subsequent sepsis during a readmission within 90 days after discharge. In all, researchers examined 9.4 million adult patient visits.
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The study found 0.6 percent of patients had sepsis during readmission within 90 days of discharge. Researchers also saw an association between exposure to a high-risk antibiotic during the first hospital visit and a greater sepsis risk during readmission, compared to patients with no antibiotic exposure. Researchers noted high-risk antibiotics had a high likelihood of microbiome disruption.
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