Researchers from Cleveland Clinic evaluated about 1,000 EHRs between January 2015 and July 2023 among patients who were taking anti-obesity medications. The EHRs were collected from a large health system in Ohio and Florida.
The weight loss drug with the highest adherence was Wegovy (semaglutide), with 40% of Wegovy patients still filling prescriptions after a year. In comparison, the adherence of orlistat, liraglutide, naltrexone-bupropion and phentermine-topiramate after 12 months ranged between 0% and 19%.
The findings show another aspect to the increased popularity of glucagon-like peptide-1 receptor agonists like Wegovy. In October, a first-of-its-kind study from a California hospital system found an “exponential” increase in patients using Wegovy, Mounjaro and other GLP-1s.
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