Active drug shortages in the U.S. rose for the second consecutive quarter in 2026, reaching 223 in the first quarter, according to the American Society of Health-System Pharmacists — and the FDA’s database continues to reflect new discontinuations weekly. The database is updated daily to reflect manufacturing recoveries, regulatory actions and how shortages are classified — not solely day-to-day availability at the hospital level.
Here are eight recent drug shortages, according to the FDA database:
- Dexmedetomidine hydrochloride injection: Slayback Pharma discontinued the 4-microgram/milliliter formulation in two presentations on June 5.
- Dacomitinib tablet: Pfizer discontinued all three strengths of Vizimpro, including 15-, 30- and 45-milligram tablets, on June 8.
- Leflunomide tablet: Sanofi-Aventis discontinued all three strengths of Arava (10, 20 and 100 milligrams) as well as two generic leflunomide presentations on June 8.
- Ifosfamide injection: Currently in shortage as of June 12. Baxter Healthcare lists the 3-gram/60-milliliter presentation as unavailable with an estimated recovery of October 2026; Fresenius Kabi and Hikma Pharmaceuticals also report limited or backordered supply, with next releases expected in the June–August timeframe.
- Donepezil hydrochloride; memantine hydrochloride capsule, extended release: Amneal Pharmaceuticals discontinued both the 10-milligram/14-milligram and 10-milligram/28-milligram extended-release capsule formulations on June 15.
- Lorlatinib tablet: Pfizer discontinued the 120-tablet bottle configuration of Lorbrena 25 milligrams on June 15, with supply expected to exhaust on June 30. The 30-tablet bottle presentation will continue to be manufactured.
- Emtricitabine capsule: Gilead Sciences discontinued the Emtriva 200-milligram capsule on June 17, but the product is expected to remain available until March 2027.
- Emtricitabine oral solution: Gilead Sciences discontinued the Emtriva 10-milligram/milliliter oral solution on June 17, but the product is expected to remain available until March 2027.
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