Nearly 75% of active drug shortages in the U.S. began in 2022 or earlier, with some persisting for more than five years.
According to a report from the American Society of Health-System Pharmacists released in September, the number of active shortages declined to 214 in the third quarter of 2025 — the lowest since early 2018 and a steep drop from the record 323 reported in the first quarter of 2024. While the trend is improving, the ASHP warned that persistent shortages of commonly used medications, including lorazepam and triamcinolone injections, continue to disrupt care.
Long-term shortages now account for most active disruptions, with the ASHP noting that nearly 75% began in 2022 or earlier. These prolonged gaps in supply often require health systems to modify treatment plans, locate alternatives and update clinical workflows.
The operational strain on health systems remains considerable. Pharmacy staff must adjust automation systems and EHRs to reflect real-time availability, even as many hospitals continue to face workforce shortages. The ASHP said the time and resources required to manage shortages add complexity that can delay patient care.
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