- Baptist Medical Center (San Antonio) — 1,389
- Methodist Hospital (San Antonio) — 1,353
- Memorial Hermann Southwest Hospital (Houston) — 1,147
- The Methodist Hospital (Houston) — 923
- Baylor University Medical Center at Dallas (Dallas) — 875
- Ben Taub General Hospital (Houston) — 875
- Covenant Medical Center – Lakeside (Lubbock) — 860
- Parkland Health & Hospital System (Dallas) — 764
- CHRISTUS Spohn Hospital Corpus Christi – Memorial (Corpus Christi) — 739
- Memorial Hermann Hospital – Texas Medical Center (Houston) — 726
Source: American Hospital Directory. Read the complete list of statistics for hospitals in Texas, including total discharges, patient days and gross patient revenue here.