Largest trial to study prevention of heart failure in childhood cancer survivors concludes

City of Hope and Children’s Oncology Group researchers conducted the largest clinical trial to date to investigate the prevention of childhood cancer survivors from developing heart failure.

Advertisement

The study, published Jan. 9 in The Lancet Oncology, included 30 hospitals in the U.S. and Canada and about 182 patients. Patients were either given placebo or carvedilol, a blood vessel relaxing medication, for two years.

There were no significant differences in side effects from carvedilol and placebo.The trial did not demonstrate the goal of showing decreases in the thinning of the heart muscle and enlargements of its chambers, two side effects of a class of chemotherapy drug that can result in eventual heart failure among long-term cancer survivors. There was significant improvement, however, in heart left ventricular end-systolic wall stress, according to a Jan. 9 City of Hope press release.

“This study is an important first step toward developing future studies that will seek to optimize the long-term well-being and health of survivors who are expected to live for decades after their initial cancer diagnosis,” the press release said. 

At the Becker's 11th Annual IT + Revenue Cycle Conference: The Future of AI & Digital Health, taking place September 14–17 in Chicago, healthcare executives and digital leaders from across the country will come together to explore how AI, interoperability, cybersecurity, and revenue cycle innovation are transforming care delivery, strengthening financial performance, and driving the next era of digital health. Apply for complimentary registration now.

Advertisement

Next Up in Uncategorized

Advertisement

Comments are closed.