The Hospital of the University of Pennsylvania is nationally recognized for its excellence in medical research, education and patient care. It is one of seven acute care hospitals that comprise the University of Pennsylvania Health System, a part of Penn Medicine. Founded as the first university-owned teaching hospital in the United States, the hospital is now more than 150 years old, continuing its mission to improve lives through groundbreaking care and discovery. As the flagship of the health system, the hospital is closely linked to the Perelman School of Medicine and the University of Pennsylvania, serving as the clinical epicenter of the organization’s interconnected education and research missions. It offers an immersive training environment for future physicians and scientists, hosts numerous pioneering clinical trials, and benefits from Penn Medicine’s $580 million in annual National Institutes of Health grant funding to drive the development of new treatments and cures. Notable areas of clinical and research excellence include oncology, cardiology and neurology. The hospital is also home to the Clifton Center for Medical Breakthroughs, which is a 1.5 million-square-foot, 17-story facility that stands as the largest capital project in the university’s history. The center features 504 private patient rooms and 47 operating rooms, designed to deliver the treatments of tomorrow, today. Hospitals of the University of Pennsylvania-Penn Presbyterian was named among the U.S. News & World Report‘s honor roll for 2025-26, regionally ranked as best in the state and in Philadelphia.
