Mr. Lefteris leads UCI Health, one of California’s largest academic health systems and the only one in Orange County, Calif. The system has grown from a single hospital to seven facilities across two counties since he took the helm in 2020. The 1,461-bed system includes UCI Health—Orange, UCI Health—Irvine, four community hospitals and an affiliated physician network, as well as the UCI Health—Irvine Rehabilitation Hospital that opened in July 2026. In December 2025, UCI Health—Irvine became the nation’s first all-electric acute care hospital, on track for LEED Platinum certification as part of the system’s broader sustainability commitments. Mr. Lefteris also oversees UCI Health Ventures, which invests in healthcare innovation and digital health, and he serves as California’s state delegate to the American Hospital Association’s Regional Policy Board 9. Under his leadership, UCI Health—Orange, the system’s flagship, has received the “Beacon Award for Excellence” from the American Association of Critical-Care Nurses for numerous nursing units, an “A” grade in Leapfrog’s twice-yearly hospital safety grade, and recognition from Vizient as one of the nation’s top 10 academic medical centers for high-quality care. In 2025, the Orange County Register named Mr. Lefteris one of the most influential people in Orange County.
