Here are the number of drug overdose deaths per 100,000 residents in all 50 states in 2020, in descending order:
Note: Rates are adjusted for age distribution and population size but do not account for other state-specific population characteristics.
1. West Virginia: 81.4
2. Kentucky: 49.2
3. Delaware: 47.3
4. Ohio: 47.2
5. Tennessee: 45.6
6. Maryland: 44.6
7. Louisiana: 42.7
8. Pennsylvania: 42.4
9. Maine: 39.7
10. Connecticut: 39.1
11. New Mexico: 39
12. Rhode Island: 38.2
13. Indiana: 36.7
14. Arizona: 35.8
15. Florida: 35
16. South Carolina: 34.9
17. Massachusetts: 33.9
18. Vermont: 32.9
19. New Jersey: 32.1
19. Missouri: 32.1
21. North Carolina: 30.9
22. New Hampshire: 30.3
23. Michigan: 28.6
24. Illinois: 28.1
25. Wisconsin: 27.7
26. Virginia: 26.6
27. Nevada: 26
28. New York: 25.4
29. Colorado: 24.9
30. Alabama: 22.3
31. Washington: 22
31. Alaska: 22
33. California: 21.8
34. Mississippi: 21.1
35. Utah: 20.5
36. Oklahoma: 19.4
37. Arkansas: 19.1
38. Minnesota: 19
39. Oregon: 18.7
40. Hawaii: 18.3
41. Georgia: 18
42. Wyoming: 17.4
42. Kansas: 17.4
44. Idaho: 15.9
45. North Dakota: 15.6
45. Montana: 15.6
47. Iowa: 14.3
48. Texas: 14.1
49. Nebraska: 11.3
50. South Dakota: 10.3