The 72nd annual Fortune 500 list was published June 3, ranking the largest U.S. companies by revenue.
Here are five takeaways for healthcare leaders:
1. Five healthcare medical facilities companies were included in the top 500, including Nashville, Tenn.-based HCA Healthcare at No. 60 overall, followed by Dallas-based Tenet Healthcare (214), King of Prussia, Pa.-based Universal Health Services (255), Denver-based DaVita (331) and Franklin, Tenn.-based Community Health Systems (350).
2. Nine insurers were in the top 500, with Eden Prairie, Minn.-based UnitedHealth Group landing at No. 3 overall. Woonsocket, R.I.-based CVS Health and Bloomfield, Ct.-based The Cigna Group followed at 6 and 14, respectively. Other payers included were Indianapolis-based Elevance Health (18), St. Louis-based Centene (19), Louisville, Ky.-based Humana (34), Long Beach, Calif.-based Molina Healthcare (104), Jacksonville, Fla.-based GuideWell (14) and New York City-based Oscar Health (376).
3. Oscar Health saw the largest jump in rank, from 437 in 2025 to 376 in 2026. The company was founded in 2012 and serves more than 1 million members.
4. For the first time in 13 years, Walmart no longer holds the No. 1 spot. Amazon was ranked first, bumping Walmart to No. 2 where it was in 2012. Amazon debuted on the list at No. 492 in 2002. Amazon made $716 billion in revenue in fiscal 2025, up 12.4%, compared to Walmart’s $713 billion, up 4.7%.
5. The four most profitable companies combined to 22% of the entire Fortune 500’s earnings: Alphabet, Nvidia, Apple and Meta, which each made more than $100 billion in profits.
Here are the top 25 ranked healthcare companies, along with their revenue and percentage change to annual revenue:
1. UnitedHealth Group (No. 3 on Fortune 500)
2025 revenue: $447.57 billion
Change to revenue: 11.8%
2. CVS Health (No. 6 on Fortune 500)
2025 revenue: $402.07 billion
Change to revenue: 7.9%
3. McKesson (No. 8 on Fortune 500)
2025 revenue: $359.05 billion
Change to revenue: 16.2%
4. Cencora (No. 10 on Fortune 500)
2025 revenue: $321.33 billion
Change to revenue: 9.3%
5. Cigna Group (No. 14 on Fortune 500)
2025 revenue: $274.90 billion
Change to revenue: 11.2%
6. Cardinal Health (No. 15 on Fortune 500)
2025 revenue: $222.58 billion
Change to revenue: -1.9%
7. Elevance Health (No. 18 on Fortune 500)
2025 revenue: $199.13 billion
Change to revenue: 12.5%
8. Centene (No. 19 on Fortune 500)
2025 revenue: $194.78 billion
Change to revenue: 19.4%
9. Humana (No. 34 on Fortune 500)
2025 revenue: $129.66 billion
Change to revenue: 10.1%
10. Johnson & Johnson (No. 45 on Fortune 500)
2025 revenue: $94.19 billion
Change to revenue: 6.1%
11. HCA Healthcare (No. 60 on Fortune 500)
2025 revenue: $75.60 billion
Change to revenue: 7.1%
12. Eli Lilly (No. 67 on Fortune 500)
2025 revenue: $65.18 billion
Change to revenue: 44.7%
13. Merck (No. 68 on Fortune 500)
2025 revenue: $65.01 billion
Change to revenue: 1.3%
14. Pfizer (No. 73 on Fortune 500)
2025 revenue: $62.58 billion
Change to revenue: -1.7%
15. AbbVie (No. 77 on Fortune 500)
2025 revenue: $61.16 billion
Change to revenue: 8.6%
16. Oracle (No. 82 on Fortune 500)
2025 revenue: $57.40 billion
Change to revenue: 8.4%
17. Bristol-Myers Squibb (No. 97 on Fortune 500)
2025 revenue: $48.19 billion
Change to revenue: -0.2%
18. Molina Healthcare (No. 104 on Fortune 500)
2025 revenue: $45.43 billion
Change to revenue: 11.8%
19. Thermo Fisher Scientific (No. 106 on Fortune 500)
2025 revenue: $44.56 billion
Change to revenue: 3.9%
20. Abbott Laboratories (No. 107 on Fortune 500)
2025 revenue: $44.33 billion
Change to revenue: 5.7%
21. Amgen (No. 129 on Fortune 500)
2025 revenue: $36.75 billion
Change to revenue: 10%
22. Gilead Sciences (No. 153 on Fortune 500)
2025 revenue: $29.44 billion
Change to revenue: 2.4%
23. Medline (No. 159 on Fortune 500)
2025 revenue: $28.43 billion
Change to revenue: 11.5%
24. Stryker (No. 181 on Fortune 500)
2025 revenue: $25.12 billion
Change to revenue: 11.2%
25. Danaher (No. 186 on Fortune 500)
2025 revenue: $24.57 billion
Change to revenue: 2.9%
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