Study: High-dose flu vaccine more effective for elderly patients than standard-dose vaccine

Among persons 65 years of age or older, a high-dose, inactivated influenza vaccine proved to be more effective against influenza than a standard-dose vaccine, according to a study published in The New England Journal of Medicine.

Researchers conducted a trial a high-dose flu vaccine — IIV3-HD — with a standard-dose vaccine — IIV3-SD. A total of 31,989 participants were enrolled from 126 research centers in the United States and Canada. Around 15,991 were randomly assigned to receive IIV3-HD and 15,998 to receive IIV3-SD.

According to the study:

•    Approximately 1.4 percent of participants in the high-dose group had laboratory-confirmed influenza as compared to 1.9 percent of the standard-dose group.
•    At least one serious adverse event during the safety surveillance period was reported by 8.3 percent of the participants in the high-dose group as compared with nine of the participants in the standard-dose group.
•    The high-dose vaccine induced significantly higher antibody responses and provided better protection against laboratory-confirmed influenza illness than the standard-dose vaccine.

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