New ibuprofen formulation could help curb opioid use

A new iburprofen composition holds the potential to change pain medication prescription practices, according to a recent study published in The FASEB Journal.

For the study, researchers observed the way arginine iburprofen works in the blood cells of rats and mice. Arginine is an amino acid used in the body to synthesize proteins, which can also restore blood pressure to normal levels. Study results demonstrated that ibuprofen arginine worked just like regular arginine in terms of stabilizing blood pressure. Arginine formulations of ibuprofen could counteract the harmful cardiovascular consequences caused by high doses of conventional iburprofen, allowing the medication to be delivered in higher doses.

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"This is a nifty idea and the results are clear," said Thoru Pederson, PhD, editor-in-chief of The FASEB Journal. "The potential for human use is attractive, not only for attenuating the cardiovascular risk, but also to the extent that this formulation may circumvent moving certain patients onto opioid painkillers, fraught with their own dangers."

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