CRE sepsis cases rose significantly over 3-year period

A study published in the American Journal of Infection Control examined incidence rates, risk factors and outcomes for infections caused by carbapenem-resistant gram-negative bacilli.

Researchers conducted the retrospective cohort study at an urban tertiary care academic medical center. They identified 448 patients, 18 years and older, admitted from 2012 to 2015 who were culture positive for carbapenem-resistant Enterobacteriaceae or carbapenem-resistant non-Enterobacteriaceae from any site.

Of the 448 patients, 111 had CRE and 337 had CRNE. CRE sepsis cases increased significantly over the study period. The increase was mainly driven by increasing incidence of Enterobacter spp. infection.

There was no difference in hospital survival between CRE sepsis patients and CRNE sepsis patients.

"Dramatic increases in CRE, particularly Enterobacter spp., appear to be causing a shift in the burden of clinically significant carbapenem-resistant gram-negative infection," researchers concluded.

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