The fashion brand will make its first donation of $250,000 to the Crisis Text Line, a nonprofit that supports people in crisis through a text-messaging service.
The company also is encouraging the public to donate and will match their donations up to $100,000.
Ms. Spade was found dead by suicide June 5 in her New York City apartment.
More articles on population health:
Gaming disorder now a WHO-recognized disease, but US healthcare system not prepared for treatment
Fixing the medical staff shortage problem in rural areas
Viewpoint: Family separation is a health crisis