In this episode, Girish N. Nadkarni, MD, MPH, Barbara T. Murphy Chair of the Windreich Department of Artificial Intelligence and Human Health, Director of the Hasso Plattner Institute for Digital Health, Irene and Dr. Arthur M. Fishberg Professor of Medicine at the Icahn School of Medicine, and Chief AI Officer of the Mount Sinai Health System, and Nicholas Gavin, MD, MBA, MS, Vice President and Chief Clinical Innovation Officer at Mount Sinai Health System, discuss building AI governance and assurance frameworks, expanding asynchronous care, and using generative AI to improve access, efficiency, and patient centered innovation.