Since assuming the role of CEO in 2022, Dr. Cacchione has led Jefferson through one of the most transformative periods in its 200-year history, positioning it as a national leader in healthcare innovation, education and community impact. Under his leadership, Jefferson has grown into a $15 billion nonprofit enterprise encompassing more than 30 hospitals, 700 care sites, a nationally recognized research university, and a health plan serving over 360,000 members across Pennsylvania and New Jersey. Dr. Cacchione has driven landmark achievements, including Jefferson’s combination with Lehigh Valley Health Network, the integration of Jefferson Health Plans and the opening of Jefferson Honickman Center, an outpatient facility in Philadelphia. His tenure has also seen the system’s Sidney Kimmel Cancer Center earn the National Cancer Institute’s comprehensive cancer center designation, $300 million in philanthropic gifts and more than $1.5 billion in community benefit delivered over two years. A visionary physician-leader, Dr. Cacchione unites Jefferson’s academic, clinical and insurance arms to improve access, strengthen workforce development and advance health equity. Prior to joining Jefferson, Dr. Cacchione served as executive vice president of clinical and network services throughout the enterprise for St. Louis-based Ascension, one of the nation’s largest health systems.
