Dr. Brennan serves as senior vice president and chief medical officer of the University of Pennsylvania Health System, where he oversees healthcare quality, patient safety, regulatory affairs and medical affairs across seven hospitals and an extensive outpatient network delivering millions of visits annually. He leads systemwide initiatives to strengthen clinical accountability, regulatory readiness and measurable improvements in patient outcomes across a $12.5 billion academic health enterprise with more than 50,000 faculty and staff. An infectious diseases specialist, Dr. Brennan previously chaired the healthcare infection control practices advisory committee, advising senior U.S. health officials on national infection prevention and disease control policy. His expertise in infection control and public health has shaped operational strategy across Penn Medicine and informed leadership roles at various hospitals across the system. He also serves on the inaugural board of health for the Delaware County Health Department, extending his impact into regional public health governance. In addition, Dr. Brennan serves as the official host city medical lead for FIFA World Cup 26 Philadelphia, overseeing medical planning and coordination for one of the world’s largest sporting events.
