The O’Neal Comprehensive Cancer Center at the University of Alabama at Birmingham is the only NCI-designated comprehensive cancer center in a four-state region. With more than 400 physicians and researchers serving over 10,000 new patients annually, the center leads transformative advances in cancer prevention, treatment and clinical research. Between 2020 and 2024, the center nearly doubled its clinical trials faculty and expanded infrastructure through a $1.5 million investment, resulting in a 50% increase in patient enrollment and more than 200 active oncology trials. In 2025, the launch of the Academic Research Organization for Clinical Trials further streamlined study operations across UAB’s schools. UAB O’Neal has shaped national cancer policy and championed federal research investment, while maintaining a strong regional focus on access and health equity. Recent innovations include the launch of a Saturday infusion clinic, an online second-opinion platform and initiation of tumor-infiltrating lymphocyte therapy for melanoma. Supported by $71.1 million in research and training funding, the O’Neal Cancer Center continues to advance discovery and accelerate access to cutting-edge therapies.
