Mr. Mahoney leads the University of Pennsylvania Health System, the clinical enterprise of Penn Medicine, overseeing seven hospitals, 13 multispecialty centers, and hundreds of outpatient facilities across Pennsylvania, Delaware and New Jersey. He joined the organization in 1996, and served in leadership roles across nearly three decades before being appointed CEO in 2019. Among his most significant accomplishments is the creation of the Clifton Center for Medical Breakthroughs, the largest capital project in the University of Pennsylvania’s history and one of the largest hospital projects in the nation. The center is a $1.6 billion, 1.5-million-square-foot hospital featuring 47 operating rooms and 504 private patient rooms. He has continued to expand Penn Medicine’s reach through the addition of Penn Medicine Doylestown (Pa.) Health in 2025, construction of a new multispecialty outpatient center in Montgomeryville, Pa., a fourth proton therapy site, and new cancer and imaging facilities at Penn Medicine Princeton Medical Center in Plainsboro, N.J. He also played a role in the launch of the Lurie Autism Institute, in collaboration with Children’s Hospital of Philadelphia. Mr. Mahoney co-founded the Fund for Health, which has contributed $1.6 million to nine early-stage businesses addressing social determinants of health in underserved communities, and has championed AI-driven innovations including ambient listening technologies and “Chart Hero,” a Penn Medicine-developed tool that surfaces clinically meaningful insights to support faster, more informed decision-making. He serves on the boards of the Chamber of Commerce for Greater Philadelphia, the Science Center, and the Committee of Seventy, and is a senior fellow of the Leonard Davis Institute of Health Economics.
