Dr. Cacchione has served as CEO of Jefferson since 2022, providing strategic leadership for a comprehensive system that includes Jefferson Health, Thomas Jefferson University and Jefferson Health Plans, which collectively serve millions of patients, 8,300 students and more than 350,000 insurance members annually. His tenure has been marked by significant advances in technology integration, patient care quality and innovative solutions that expand access to care, firmly positioning Jefferson as a leader in modern healthcare delivery. Among his most notable technology initiatives is Jefferson’s “Virtual Checkout” system, a national first that streamlines the patient experience by allowing remote staff to schedule follow-ups and address questions before patients leave the exam room. He is also leading the charge for an ambitious AI strategy aimed at reclaiming over 10 million hours of clinician time by 2028. Under his leadership, Jefferson has earned 12 “A” hospital safety grades from The Leapfrog Group, achieved Magnet redesignation across multiple hospitals in 2025, and received top rankings from U.S. News & World Report in eight distinct specialties. Dr. Cacchione has also deepened Jefferson’s community impact through his bicentennial service initiative, which generated 212,000 volunteer hours across 4,000 community projects, alongside expanded mobile health, telehealth and language access services that reach underserved populations across 33 hospitals and 700-plus outpatient sites. He serves on the board of the University City Science Center, and as policy committee chair and executive committee member of the Chamber of Commerce for Greater Philadelphia. His leadership has earned him recognition as a “Trailblazer in Healthcare” by City & State PA, and The CEO Forum Group named him one of the “Top 10 CEOs Transforming Healthcare in America” for three consecutive years.
