Sanford USD Medical Center is the largest hospital in South Dakota and serves as a teaching hospital for the University of South Dakota Sanford School of Medicine. The medical center offers comprehensive care, including emergency air transport, neonatal and pediatric intensive care, transplant services, and specialty centers in children’s care, heart, cancer, neuroscience, sports medicine and women’s health. With 545 beds and 4,000 employees, Sanford USD Medical Center is the only level 1 adult and level 2 pediatric trauma center in South Dakota verified by the American College of Surgeons. The hospital participates in the “Increasing Organ Transplant Access” model and has been a Magnet-recognized organization for nursing excellence since 2003, earning the designation five consecutive times. U.S. News & World Report ranked Sanford USD Medical Center the No. 1 hospital in South Dakota in its 2026-2027 “Best Regional Hospitals” rankings, recognizing it as a top-performing general medical and surgical facility. Sanford Health is adding a new clinic space on the Sanford USD Medical Center campus to provide dermatology and plastic surgery services, with the work expected to complete at the end of 2027.
