Study: Gastric suppression drugs linked to higher risk of C. diff recurrence

Gastric suppression medication use increases risk of recurrent Clostridium difficile infection, according to a study conducted by Rochester, Minn.-based researchers and published in JAMA Internal Medicine.

The researchers examined the effect of gastric suppression medications on C. diff recurrence. The medications studied included:

●    Proton pump inhibitors, such as omeprazole
●    Histamine 2 blockers, such as ranitidine

Sign up for our FREE E-Weekly for more coverage like this sent to your inbox

These over-the-counter drugs are commonly prescribed. The researchers conducted a systematic review and meta-analysis of 16 studies with 7,703 patients suffering from C. diff.

Of the 7,703 patients, 1,525 developed recurrent C. diff. The rate of recurrent C. diff in patients using gastric suppression drugs was 22.1 percent, as compared to 17.3 percent in patients who were not using the medications.

"It may be reasonable to re-evaluate the need for these medications in patients with C. diff," said Sahil Khanna, MBBS, a gastroenterologist at Mayo Clinic and senior author of the study.

More articles on healthcare quality:
Redesigned Olympus scopes linked to superbug outbreak: 7 things to know
While influenza A declines, influenza B makes late-season surge
Rare strep infection leads to amputation of hands, feet

© Copyright ASC COMMUNICATIONS 2019. Interested in LINKING to or REPRINTING this content? View our policies by clicking here.


IC Database-3

Top 40 Articles from the Past 6 Months