Integrins are cell surface receptors that mediate interactions between cells and their surroundings. By targeting integrins with certain antigens, scientists blocked capillary leakage associated with many difficult-to-cure diseases, including sepsis.
“Sepsis may develop unexpectedly and proceed fast. When the patients arrive at the hospital, the disease may have already progressed,” said study author Dr. Pipsa Saharinen, a researcher at the University of Helsinki and Wihuri Research Institute. “It would be important to have the means to inhibit vessel leakiness and the development of a more severe disease.”
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