Researchers studied data from surveys of middle-aged individuals from the Middle Aged Danish Twin study and older individuals from the Longitudinal Study of Aging Danish Twins. The researchers examined 2,346 middle-aged individuals who underwent cognitive assessments over a 10-year period, and 2,475 older individuals underwent the assessments over a two-year period.
They also determined cumulative use of PPIs two years prior to study enrollment and during follow up using data from a nationwide prescription register.
In the study of middle-aged individuals, the adjusted difference in mean cognitive scores of those with high consumption of PPI was lower than that of non-users.
In the longitudinal study, individuals with high consumption of PPI had higher adjusted mean cognitive scores than non-users.
Researchers found that no stated differences in cognitive scores between PPI users and non-users were significant.
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