In phase 3 study, experimental prostate cancer drug reduces death risk by 58%

A prostate cancer drug candidate from Pfizer and Astellas Pharma reduced the risk of metastasis or death by 58 percent in a phase 3 trial, the two drugmakers said April 29. 

The potential oncology treatment, Xtandi (enzalutamide) and leuprolide, was tested among about 1,000 patients with non-metastatic hormone-sensitive prostate cancer with high-risk biochemical recurrence. 

The study compared Xtandi and leuprolide, Xtandi alone and a placebo plus leuprolide, and the research's primary endpoint was metastasis-free survival. The Xtandi monotherapy reduced the risk of metastasis or death by 37 percent.

For the secondary endpoint, prostate-specific antigen progression, Xtandi plus leuprolide and Xtandi monotherapy reduced the risk, respectively, by 93 percent and 67 percent.

The two companies said they will use the data "to support a potential regulatory submission for Xtandi in this indication in 2023."

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