Researchers randomized 20 morbidly obese patients to two groups receiving either 200 mg or 350 mg of propofol over 60 seconds for induction of anesthesia. In the 200 mg group, bispectral index values were more variable and higher than in the 350 mg group. Also, 20 percent of patients in the 200 mg group required an additional propofol dose, whereas no patients in the 350 mg group require more anesthesia, according to the study.
Although the 350-mg propofol dose appeared to be more effected in this patient population, researchers noted that this dose required more study before it could be recommended.
Read the study on propofol use in morbidly obese patients.
