Researchers conducted a multicenter, randomized trial inclusive of 2,157 women. They randomly assigned women, who were undergoing their first in vitro fertilization cycle, to undergo either fresh embryo transfer (50.2 percent) or embryo cryopreservation followed by frozen embryo transfer (48.7 percent). The primary outcome was a live birth after the first embryo transfer.
The study shows that the live birth rate did not differ significantly between the frozen embryo group and the fresh embryo group. Additionally, there were no significant differences between the groups with regard to:
• Rates of implantation
• Clinical pregnancy
• Overall pregnancy loss
• Ongoing pregnancy
Researchers also found frozen embryo transfer resulted in a significantly lower risk of the ovarian hyperstimulation syndrome as compared to fresh embryo transfer
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