Use of early-onset sepsis calculator results in fewer antibiotics for newborns

Using an early-onset sepsis calculator can substantially reduce antibiotic therapy for newborns, according to a study published in JAMA Pediatrics.

Researchers conducted searches in Medline, Embase, Web of Science and Google Scholar from 2011 through Jan. 31 to find studies with original data that compared antibiotic management guided by the early-onset sepsis calculator with conventional strategies to manage antibiotic therapy for newborns suspected of having early-onset sepsis.

They examined 13 relevant studies analyzing a total of 175,752 newborns. All the studies showed a substantially lower relative risk of antibiotic therapy when using the calculator.

Although evidence on safety was limited, researchers found that the proportion of missed early-onset sepsis cases was similar when using the calculator and when using conventional strategies.

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