Can FMT clear CRE, VRE from the digestive tract?

Anuja Vaidya (Twitter) - Print  | 

A study published in the Journal of Hospital Infection examined whether fecal microbiota transplantation can effectively clear Carbapenem-resistant Enterobacteriaceae and Vancomycin-resistant enterococci from carriers.

Researchers conducted a multicenter trial on adult patients with CRE or VRE digestive tract colonization. The patients received FMT between January 2015 and April 2017. They excluded patients with immunosuppression or concomitant antibiotic prescription at the time of FMT. They determined successful decolonization by at least two consecutive negative rectal swabs on days seven, 14, 21 and 28 as well as monthly over three months following FMT.

For the 17 patients included in the study, median duration of CRE or VRE carriage before FMT was 62.5 days. The study shows one week after FMT, three of eight patients were free from CRE colonization and three of nine from VRE. After three months, four of eight patients were free from CRE colonization and seven of eight from VRE. Three patients in each group received antibiotics during follow-up. No adverse events were reported.

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