Antibiotics have more negative side effects than previously thought, study finds

While researchers have known that antibiotics can cause unwanted gastrointestinal side effects for some time, a new study shows that overuse of antibiotics can wreak havoc on the immune system, glucose metabolism and food absorption as well as effect stress and behavior.

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Researchers from Oregon State University studied the effects of four antibiotics that are frequently given to lab animals.

“Prior to this most people thought antibiotics only depleted microbiota and diminished several important immune functions that take place in the gut,” said Andriy Morgun, MD, PhD, assistant professor in the OSU College of Pharmacy. “Actually that’s only about one-third of the picture. They also kill intestinal epithelium. Destruction of the intestinal epithelium is important because this is the site of nutrient absorption, part of our immune system and it has other biological functions that play a role in human health.”

Overall, the OSU researchers found that powerful long-term use of antibiotics can have more far-reaching effects on human health than previously thought. Their findings were published online in the journal Gut.

More articles on antibiotic use:
Obama administration seeks $1.2B to combat antibiotic-resistant bacteria
Antibiotics overprescribed in 45% of patients in outpatient settings
Newly discovered antibiotic fights infection without bacteria developing resistance 

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