GLP-1s and heart outcomes: 5 recent findings

With deaths from obesity-related heart disease reportedly increasing by 180% over the past 20 years, more research is being done to learn how GLP-1 medications such as Ozempic, Wegovy, Mounjaro and Zepbound can address outcomes in cardiovascular health. 

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Here are five recent research findings:

  1. Among patients with Type 2 diabetes, GLP-1 medications reduced major adverse cardiovascular events by 13% when compared to a placebo.
  2. Tirzepatide, the active ingredient in Eli Lilly’s GLP-1 medications Mounjaro and Zepbound, reduced the risk of heart failure by 46% and the risk of both heart failure or cardiovascular death by 38% among individuals with obesity.
  3. Stroke survivors who took GLP-1 or SGLT2 medications had a 74% lower risk of death and an 84% lower risk of heart attack compared to patients who did not take either medication.
  4. The death rate among stroke survivors who took either a GLP-1 or an SGLT2 was 11.8% and the heart attack rate was 1.5%, compared to 54% and 6.1%, respectively, for patients who did not take either medication.
  5. Semaglutide, the active ingredient in Novo Nordisk’s GLP-1 medications Ozempic and Wegovy, reduced annual healthcare costs by $7,502 for patients with overweight or obesity, and by $9,276 for patients with heart failure or atherosclerotic cardiovascular disease.
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